99 results
Fever - Pyrogen Pathophysiology

EXOGENOUS PYROGEN
 • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins
 •
Pathophysiology EXOGENOUS ... components Exogenous ... , IFN, IL-6 ENDOGENOUS ... vasculature via: • Active ... organs CNS - Endogenous
Staging of Skin Mottling

Mottling is less sensitive, but more specific for hypoperfusion and elevated mortality (figure
Mottling suggests active ... endogenous vasoconstriction ... not additional exogenous
Cephalosporins 
Cephalosporins are bactericidal beta-lactam antibiotics derived from the fungus Acremonlum— they disrupt peptidoglycan formation in
They have no activity ... predominantly active ... progressively more active ... gram-positive activity ... Classification #pharmacology
Rigors And Bacteremia - Overview

• Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: → Exogenous ... pro-inflammatroy mediators (Endogenous ... Pyrogen) → Endogenous ... vasculature via: • Active ... circumventricular organs CNS: Endogenous
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Succinylcholine) • Exogenous ... pathophysiology #pharmacology
Severe Ulcerative Colitis - Management Algorithms
 - Adult outpatients with moderate to severely active ulcerative colitis
moderate to severely active ... Algorithm #treatment #gastroenterology
Forrest Classification of Upper GI Bleeding
Acute Hemorrhage
  Ia - Active Spurting, Re-bleeding Risk 60-100%
Hemorrhage Ia - Active ... 60-100% Ib - Active ... Lesions without Active ... diagnosis #endoscopy #gastroenterology
Benzodiazepines: Mechanism of Action and Side Effects
 • Decr spinal cord activity -> Muscle relaxant
Decr spinal cord activity ... amygdala-centered circuit activity ... cerebral cortex activity ... Benzodiazepines #Psychiatry #Pharmacology
Hemodynamic Effects of Long-Term Administration of Antihypertinsive Agents
Effects on Heart Rate, Cardiac Output, Total Peripheral Resistance,
, Plasma Renin Activity ... #medications #pharmacology
Systemic Glucocorticoid Dose Equivalents. 

Note: approximate equivalent dose is based on anti-inflammatory potency. Fludrocortisone is not
mineralocorticoid activity ... anti-inflammatory activity ... #Equivalents #Pharmacology