361 results
Fever - Pyrogen Pathophysiology

EXOGENOUS PYROGEN
 • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins
 •
Pathophysiology EXOGENOUS ... components Exogenous ... , IFN, IL-6 ENDOGENOUS ... vasculature via: • Active ... organs CNS - Endogenous
Staging of Skin Mottling

Mottling is less sensitive, but more specific for hypoperfusion and elevated mortality (figure
Mottling suggests active ... endogenous vasoconstriction ... not additional exogenous ... Staging #Clinical #Diagnosis
Hypercortisolism (Cushing syndrome) - Simplified Differential Diagnosis Algorithm
Exogenous (ACTH-independent)
Endogenous
 • ACTH-dependent:
    - ACTH-secreting
Simplified Differential Diagnosis ... Algorithm Exogenous ... ACTH-independent) Endogenous ... #Differential #Diagnosis
Workup for Hyperphosphatemia - Differential Diagnosis Framework
Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
- Differential Diagnosis ... Phosphate Load: • Exogenous ... Fosphenytoin • Endogenous ... #Differential #Diagnosis
Hypoglycemia - Evaluation Algorithm
Interpreting Hypoglycemia Labs - the patient must be hypoglycemic at the time of
Proinsulin - Is it endogenous ... → Exogenous Insulin ... Algorithm #workup #diagnosis
Rigors And Bacteremia - Overview

• Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: → Exogenous ... pro-inflammatroy mediators (Endogenous ... Pyrogen) → Endogenous ... vasculature via: • Active ... InfectiousDiseases #Diagnosis
Cephalosporins 
Cephalosporins are bactericidal beta-lactam antibiotics derived from the fungus Acremonlum— they disrupt peptidoglycan formation in
They have no activity ... predominantly active ... progressively more active ... gram-positive activity ... Classification #pharmacology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Succinylcholine) • Exogenous ... #differential #diagnosis ... pathophysiology #pharmacology
Exogenous Testosterone Side Effects
 • Mood disorder, Depression, Aggression
 • ↑ Erythropoiesis
 • Hypogonadism +/-BPH, prostate
Exogenous Testosterone ... BrighamChiefs #Exogenous ... SideEffects #adverse #diagnosis
Hyperthyroidism and Thyrotoxicosis Interpretation Table
 - Autonomy (Graves)
 - Autonomy (toxic nodule)
 - Exogenous thyroid hormone
toxic nodule) - Exogenous ... Interpretation #Table #diagnosis