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diagnosis management differential algorithm pharmacology rheumatology clinical causes gastroenterology syndrome hematology table nephrology infections infectiousdiseases pulmonary idsa neurology pathophysiology cardiology
Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Pathophysiology EXOGENOUS ... components Exogenous ... , IFN, IL-6 ENDOGENOUS ... vasculature via: • Active ... organs CNS - Endogenous
Hypercortisolism (Cushing syndrome) - Simplified Differential Diagnosis Algorithm Exogenous (ACTH-independent) Endogenous • ACTH-dependent: - ACTH-secreting
Diagnosis Algorithm Exogenous ... ACTH-independent) Endogenous ... adenoma (Cushing Disease
Staging of Skin Mottling Mottling is less sensitive, but more specific for hypoperfusion and elevated mortality (figure
Mottling suggests active ... endogenous vasoconstriction ... not additional exogenous
Rheumatoid Arthritis - ACR 2021 Guidelines - Low Disease Activity - Moderate to High Disease Activity
Guidelines - Low Disease ... Activity - Moderate ... to High Disease ... Activity - Methotrexate ... Tapering DMARDs - Treatment
Workup for Hyperphosphatemia - Differential Diagnosis Framework Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
Phosphate Load: • Exogenous ... Fosphenytoin • Endogenous ... acidosis, DKA Kidney Disease
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: → Exogenous ... pro-inflammatroy mediators (Endogenous ... Pyrogen) → Endogenous ... vasculature via: • Active ... circumventricular organs CNS: Endogenous
Persistent UC Symptoms Despite 5-ASA Therapies • Assess for Drug Adherence • Disease Activity Assessment (bloody
Drug Adherence • Disease ... Activity Assessment ... diarrhea correlates w active ... Escalate Treatment ... Colitis Escalate Treatment
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Chronic kidney disease ... Tuberculosis: • Endogenous ... Tuberculosis Treatment ... Initiating Treatment ... Diagnosis #Management #Treatment
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
screening for disease ... with established disease ... Individual factor activity ... Classify severity Treatment ... by a hemophilia treatment
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Chronic kidney disease ... Tuberculosis: • Endogenous ... Tuberculosis Treatment ... Initiating Treatment ... Diagnosis #Management #Treatment
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