14 results
Lactic Acidosis - Overview and Pathophysiology
Lactic acid is an endogenous substrate for gluconeogenesis, that is constantly
Lactic Acidosis ... - Overview and Pathophysiology ... Lactic acid is an endogenous ... ) Lactic Acidosis ... differential #diagnosis #pathophysiology
Oxyhemoglobin Dissociation Curve 

Left Shift - decreased unloading of O2 at tissue level (i.e.  increased
- decr H+ (alkalosis ... - incr H+ (acidosis ... Dissociation #Curve #Pathophysiology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic Alkalosis ... /L • Gastric alkalosis ... chronic respiratory acidosis ... ectopic ACTH) • Exogenous ... #Metabolic #Alkalosis
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Diagnosis and Management ... anion-gap metabolic acidosis ... Anion-Gap Metabolic Acidosis ... , Respiratory Alkalosis ... Level: 150mg/kg Management
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Associated Lactic Acidosis ... (MALA) Pathophysiology ... symptoms of metabolic acidosis ... Toxicology #Diagnosis #Management
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
by an anion gap acidosis ... pt will produce endogenous ... marked anion gap acidosis ... differential #diagnosis #management
Intercalated cells response to Metabolic Alkalosis and Metabolic Acidosis
 • Type B Intercalated Cell - "B"
response to Metabolic Alkalosis ... and Metabolic Acidosis ... Intercalated #cells #pathophysiology
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
EuDKA • Metabolic acidosis ... level < 200 mg/dL Pathophysiology ... EuDKA #diagnosis #management
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... Tuberculosis: • Endogenous ... TB #Diagnosis #Management
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
hypomagnesemia • Metabolic alkalosis ... Hypochloremic metabolic alkalosis ... Renal tubular acidosis ... diagnosis #nephrology #management ... #pathophysiology