13 results
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Naturally-occurring plant alkaloid ... • Metabolic acidosis ... Colchicine #Toxicity #Toxicology
Lactic Acidosis - Overview and Pathophysiology
Lactic acid is an endogenous substrate for gluconeogenesis, that is constantly
Lactic Acidosis ... - Overview and Pathophysiology ... Lactic acid is an endogenous ... ) Lactic Acidosis ... differential #diagnosis #pathophysiology
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
anion-gap metabolic acidosis ... Anion-Gap Metabolic Acidosis ... , Respiratory Alkalosis ... Aspirin #Toxicity #Toxicology
Oxyhemoglobin Dissociation Curve 

Left Shift - decreased unloading of O2 at tissue level (i.e.  increased
- decr H+ (alkalosis ... - incr H+ (acidosis ... Dissociation #Curve #Pathophysiology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic Alkalosis ... /L • Gastric alkalosis ... chronic respiratory acidosis ... ectopic ACTH) • Exogenous ... #Metabolic #Alkalosis
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Associated Lactic Acidosis ... (MALA) Pathophysiology ... symptoms of metabolic acidosis ... LacticAcidosis #Toxicity #Toxicology
Intercalated cells response to Metabolic Alkalosis and Metabolic Acidosis
 • Type B Intercalated Cell - "B"
response to Metabolic Alkalosis ... and Metabolic Acidosis ... Intercalated #cells #pathophysiology
Salicylate Poisoning - Toxicology

Acute toxicity = vomiting, tachypnea, tinnitus, diaphoresis, and lethargy. This may progress to
Salicylate Poisoning - Toxicology ... mixed respiratory alkalosis ... and metabolic acidosis ... Salicylate #Toxicity #Toxicology
Citrate Anticoagulation Toxicity

Hypernatremia (HyperNa):
 - Citrate solutions may have ↑ sodium content and should be paired
Anion-Gap Metabolic Acidosis ... metabolism Metabolic alkalosis ... Anticoagulation #Toxicity #toxicology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
hypomagnesemia • Metabolic alkalosis ... Hypochloremic metabolic alkalosis ... Renal tubular acidosis ... nephrology #management #pathophysiology