8 results
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Naturally-occurring plant alkaloid ... • Metabolic acidosis ... Colchicine #Toxicity #Toxicology
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
anion-gap metabolic acidosis ... Anion-Gap Metabolic Acidosis ... , Respiratory Alkalosis ... Aspirin #Toxicity #Toxicology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic Alkalosis ... /L • Gastric alkalosis ... chronic respiratory acidosis ... ectopic ACTH) • Exogenous ... #Metabolic #Alkalosis
Potassium Channel Blockers - Medications
1. Cardiovascular Drugs
2. Psychiatric drugs
3. Other drugs
4. Synthetic opioids: Levomethadyl 
5. Opium
Opium alkaloids: ... Differential #Diagnosis #Pharmacology ... #Toxicology
Salicylate Poisoning - Toxicology

Acute toxicity = vomiting, tachypnea, tinnitus, diaphoresis, and lethargy. This may progress to
Salicylate Poisoning - Toxicology ... mixed respiratory alkalosis ... and metabolic acidosis ... Salicylate #Toxicity #Toxicology ... #Pharmacology #
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
• Metabolic acidosis ... Diagnosis #Management #Pharmacology ... #Toxicity #Toxicology
Phases of Colchicine Toxicity
 - Early Phase (0-24h) 
 - Multi-organ failure Phase (1-7 days)
Metabolic: Metabolic acidosis ... Colchicine #Toxicity #Toxicology ... #Phases #Pharmacology
Citrate Anticoagulation Toxicity

Hypernatremia (HyperNa):
 - Citrate solutions may have ↑ sodium content and should be paired
Anion-Gap Metabolic Acidosis ... metabolism Metabolic alkalosis ... Anticoagulation #Toxicity #toxicology