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Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Pathophysiology EXOGENOUS ... components Exogenous ... proinflammatory mediators (endogenous ... , IFN, IL-6 ENDOGENOUS ... organs CNS - Endogenous
Hypercortisolism (Cushing syndrome) - Simplified Differential Diagnosis Algorithm Exogenous (ACTH-independent) Endogenous • ACTH-dependent: - ACTH-secreting
Diagnosis Algorithm Exogenous ... ACTH-independent) Endogenous
Hypoglycemia - Evaluation Algorithm Interpreting Hypoglycemia Labs - the patient must be hypoglycemic at the time of
Proinsulin - Is it endogenous ... → Exogenous Insulin
Workup for Hyperphosphatemia - Differential Diagnosis Framework Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
Phosphate Load: • Exogenous ... Fosphenytoin • Endogenous
Staging of Skin Mottling Mottling is less sensitive, but more specific for hypoperfusion and elevated mortality (figure
suggests active endogenous ... not additional exogenous
Chemical Eye Injury: Pathogenesis and clinical findings Exogenous chemical to the eye and/or adnexa • Ammonia, sodium
clinical findings Exogenous ... EMERGENCY: immediate management ... following initial management
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: → Exogenous ... pro-inflammatroy mediators (Endogenous ... Pyrogen) → Endogenous ... circumventricular organs CNS: Endogenous
Exogenous Testosterone Side Effects • Mood disorder, Depression, Aggression • ↑ Erythropoiesis • Hypogonadism +/-BPH, prostate
Exogenous Testosterone ... BrighamChiefs #Exogenous
Hyperthyroidism and Thyrotoxicosis Interpretation Table - Autonomy (Graves) - Autonomy (toxic nodule) - Exogenous thyroid hormone
toxic nodule) - Exogenous
Thyroid Disorders - Differential Diagnosis Algorithm Hypothyroidism: • Hasimoto’s • Radioactive Iodine • Hypopituitarism • Iodine
Thyroiditis • Exogenous
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