107 results
Fever - Pyrogen Pathophysiology

EXOGENOUS PYROGEN
 • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins
 •
Fever - Pyrogen Pathophysiology ... EXOGENOUS PYROGEN ... components Exogenous ... vasculature via: • Active ... Fever #Fever #Pathophysiology
Staging of Skin Mottling

Mottling is less sensitive, but more specific for hypoperfusion and elevated mortality (figure
Mottling suggests active ... endogenous vasoconstriction ... not additional exogenous ... Mottling #Staging #Clinical ... Diagnosis #Stages #Clinical
Rigors And Bacteremia - Overview

• Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: ... → Exogenous Pyrogen ... Pyrogen) → Endogenous ... vasculature via: • Active ... Rigors #Bacteremia #Pathophysiology
Cellular and humoral immune responses of the adaptive immune system. Activated T cells accomplish cellular immune
Exogenous antigen ... associated with CD4 ... or CD8, depending ... Endogenous antigens ... ImmuneResponses #immunology #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
Pathogenesis and clinical ... -> Particular CD4 ... harmful -> Th Cells activate ... Stevens-Johnson Syndrome ... Allergy #Immunology #pathophysiology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Severe Cushing syndrome ... ectopic ACTH) • Exogenous ... dehydrogenase activity ... Congenital AME syndrome ... loop diuretics actively
Lactic Acidosis - Overview and Pathophysiology
Lactic acid is an endogenous substrate for gluconeogenesis, that is constantly
- Overview and Pathophysiology ... Lactic acid is an endogenous ... with exercise/activity ... differential #diagnosis #pathophysiology
Cutaneous Manifestations of Monoclonal Gammopathy
 • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
• Autoantibody activity ... secretion: POEMS syndrome ... , Syndrome Schnitzler ... cutis laxa, TEMPI syndrome ... dermatology #skin #clinical
Inflammatory mechanism of asthma. 
Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
dendritic cell (DC ... antigens and thereby activate ... naive CD4 T cells ... #asthma #pathophysiology
Secondary Causes of Hypertension - Differential Diagnosis Algorithm
Hypertension - BP > 140/90 (>130/80 for DM)
Hypertensive urgency
based on repeat clinic ... • Nephritic syndrome ... Excess: • Conn's syndrome ... Licorice • Liddle's syndrome ... Steroids (Cushing's, exogenous