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diagnosis management treatment differential disease erythematosus hematology hemophagocytic hlh lupus lymphohistiocytosis systemic vasculitis workup arthritis associated barre behcet cerebritis classification
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
) Clinical Manifestations ... Demyelinating Syndrome ... Disease, PRES Pathophysiology ... #CNS #neurology ... #rheumatology #
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... rendering the immune ... non-Hodgkin lymphoma SLL ... Orange or Hep C Clinical ... • Richter’s Syndrome
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... that disrupts immune ... Autoimmune diseases: SLE ... treatment #summary #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Non-autoimmune rheumatologic ... context of primary immune ... Clinical Features ... with Lupus: • Chronic
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Summary Acute AIDP ... Guillain-Barre Pathophysiology ... : • Immune response ... Guillain-Barre Clinical ... management #treatment #neurology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
skin injury) • Neurologic ... (Clinical Dx). ... Oral aphthae : SLE ... Recurrent and chronic ... signs #symptoms #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Screening Tests for Chronic ... Complete blood count (CBC ... ANA and RF (if clinical ... diagnosis #testing #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... affects the skin, neurologic ... cognitive impairment, neurologic ... Eosinophilia, asthma, chronic ... Differential #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... Necrotizing, pauci-immune ... respiratory tracts Immune ... vasculitis, and SLE ... differential #diagnosis #rheumatology
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
HIV dementia Pathophysiology ... : The clinical ... syndrome of HAD ... disorder #dementia #AIDS ... #Neurology
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