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diagnosis management treatment cns differential erythematosus hiv lupus systemic workup arthritis associated barre cerebritis chronic classification cll cryoglobulinemia cryoglobulins dementia
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Immune-Mediated ... : • Clinical triad ... diseases: - 10% SLE ... erythematosus (SLE ... classification #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
) Clinical Manifestations ... Demyelinating Syndrome ... Disease, PRES Pathophysiology ... #CNS #neurology ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Non-autoimmune rheumatologic ... context of primary immune ... Clinical Features ... titers > 1:80 • CBC
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
HIV dementia Pathophysiology ... : The clinical ... syndrome of HAD ... #dementia #AIDS ... #Neurology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
Infection in HIV / AIDS ... should be based on clinical ... required until immune ... Suspect in movement disorders ... differential #diagnosis #AIDS
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... that disrupts immune ... Autoimmune diseases: SLE ... treatment #summary #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune ... non-Hodgkin lymphoma SLL ... Orange or Hep C Clinical ... lymphoproliferative disorders ... • Richter’s Syndrome
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Summary Acute AIDP ... Guillain-Barre Pathophysiology ... : • Immune response ... Guillain-Barre Clinical ... management #treatment #neurology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... activation of an immune ... Transverse Myelitis - Clinical ... Evaluate for NMO, SLE ... diagnosis #management #neurology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Complete blood count (CBC ... metabolic or endocrine disorders ... ANA and RF (if clinical ... diagnosis #testing #Rheumatology
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