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diagnosis management differential treatment cns rheumatology barre erythematosus guillain hematology hemophagocytic hiv hlh immune infectiousdiseases iris lupus lymphohistiocytosis opportunistic reconstitution
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
Diagnosis- Compatible syndrome ... splenomegaly Other infections ... multiple lesions Infectious ... Metastatic disease Inflammatory ... causes #radiology #neurology
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
Non-inflammatory ... Non-inflammatory ... causes: • Infectious ... MRI lesions and clinical ... #neurology #noninflammatory
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
HIV / AIDS - Differential ... should be based on clinical ... status, and focal neurologic ... differential #diagnosis #AIDS ... InfectiousDiseases #Neurology
Immune Reconstitution Inflammatory Syndrome (IRIS) - Pathophysiology Risk factors: - Low CD4 count - Disseminated OI -
Syndrome (IRIS) ... - Pathophysiology ... factors: - Low CD4 ... #Syndrome #IRIS ... #AIDS
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... production of pro-inflammatory ... accumulation of clinical ... Assessment • Clinical
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Syndrome - Overview ... treatment of HIV/AIDS ... be present: • AIDS ... noncompliance • Clinical ... initiation Clinical
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Summary Acute AIDP ... Guillain-Barre Pathophysiology ... response preceding infection ... Guillain-Barre Clinical ... management #treatment #neurology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
may precede the neurologic ... Preeclampsia, Eclampsia, Infection ... Etiology: • Pathophysiology ... Diagnosis: • Infection ... Seizures: Treat with AEDs
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
HIV dementia Pathophysiology ... : The clinical ... syndrome of HAD ... disorder #dementia #AIDS ... #Neurology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... abnormalities • Inflammatory ... likelihood of negative clinical ... neutrophil #WBC #CBC ... #hematology #pathophysiology
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