8 results
Utilization of Antibiotics as Antidotes

Valproic Acid Toxicity:
Carbapenems 

Amatoxin Mushrooms: 
Polymyxin B, Penicillin, Cyclosporine

Infographic by Mike O'Brien
@MikeEMPharmD

#Antibiotics
Utilization of Antibiotics ... Valproic Acid Toxicity ... MikeEMPharmD #Antibiotics ... #Antidotes #Toxicology ... #Pharmacology
Antifungal Azoles - Antibiotics Class Overview

Mechanism:  inhibit ergosterol synthesis (important component of fungal cell membranes)
Antifungal Azoles - Antibiotics ... hepatic, main toxicity ... Isavuconazole(PO or IV) #Pharmacology ... #Antibiotics #Review
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
Flutycosine - Antibiotics ... Thrombocytopenia) and Hepatic toxicity ... monitored to reduce toxicity ... #Pharmacology #Antibiotics ... #Review #Overview
Testicular Cancer - Treatment Related Toxicities

Bleomycin, Cisplatin, Etoposide, lfosfamide
Tinnitus & Hearing Loss
Neurotoxicity
Pulmonary Fibrosis
Hypotension
Nephrotoxicity
Skin Hyperpigmentation
Hemorrhagic Cystitis
Myelosuppression
Peripheral Neuropathy

Ashley
#chemotherapy #toxicity ... #toxicology #Toxicities ... #pharmacology # ... oncology
Drug-Induced Prolonged QTc

QTc >500ms is an independent risk factor for developing Torsades des Pointes (TdP)
Drugs causing
Risperidone • Antibiotics ... Prolonged #QTc #Toxicity ... #Toxicology #Pharmacology
Monobactam - Aztreonam - Antibiotics Class Overview

Spectrum: only has activity vs. aerobic gram negatives, no gram
- Aztreonam - Antibiotics ... combination with other antibiotics ... no significant toxicity ... #Pharmacology #Antibiotics ... #Review #Overview
Chloramphenicol - Antibiotics Class Overview

– 50S ribosomal inhibitor.   IV or PO (but PO form
Chloramphenicol - Antibiotics ... due to potential toxicity ... appropriate patients) - Toxicity ... #Pharmacology #Antibiotics ... #Review #Overview
Management of Anthracyclines and HER2 Antagonist Cardiotoxicity
Anthracyclines cause cardiomyopathy:
 ✖ Reduction in left ventricular ejection fraction
dose, concomitant exposure ... Cardiotoxicity #cardiology #oncology ... #pharmacology # ... toxicity #chemotherapy