7 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation ... Differential Diagnosis: Infection ... organ dysfuxtion, ICU ... #diagnosis #management ... #hematology #oncology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
impaired B-cell differentiation ... • Chronic lung ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Hepatopulmonary Syndrome - Diagnosis and Management Summary
A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... absence of intrinsic lung ... • Platypnea - Dyspnea ... on radioactive lung ... #treatment #hepatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
rash) • Heart, lung ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
if SSTI or port infection ... abdominal pain; full infectious ... ): - Hematologic ... Facial swelling, dyspnea ... : continue differentiating
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
starting amiodarone treatment ... respiratory distress syndrome ... Dyspnea 3. ... failure - Infectious ... Pulmonary #diagnosis #management
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
diagnose concomitant infection ... Acute Pseudogout: Treatment ... ≥2 attacks • Long-term ... Crowned Dens Syndrome ... #diagnosis #management