134 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... typically prolong aPTT ... Congenital intrinsic coagulation ... intravascular coagulation ... differential #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... , FVII, FIX, FX ... #Abnormal #PT #aPTT ... differential #hematology #coagulation
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Investigation of Abnormal Coagulation ... PT - Prolonged aPTT ... PT - Prolonged aPTT ... #Algorithm #Coagulation ... #Abnormal #APTT
Coagulation Protein Tests (PT and PTT)

#Coagulation #Tests #PTT #algorithm #differential #pathophysiology
Coagulation Protein ... Tests (PT and PTT ... ) #Coagulation ... #Tests #PTT #algorithm
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... • Prolonged PT/PTT ... levels of factors VII ... PT/INR: ↑ • PTT ... INR < 2.3 - APTT
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Evaluate an Abnormal APTT ... : Is the PT or APTT ... Prolonging the PT or APTT ... cause of Prolonged APTT ... ISNeducation #Abnormal #APTT
Coagulation Cascade Mnemonic - PITT vs PET
PITT (with an I) = Intrinsic = APTT
Coagulation Cascade ... = Intrinsic = APTT ... @pinoygastro #Coagulation
Coagulation cascade and anticoagulants 

Satyendra Dhar MD, @DharSaty

#coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
Coagulation cascade ... @DharSaty #coagulation ... vWF #thrombin #ptt
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
INR), Prolonged PTT ... INR), Prolonged PTT ... (INR), Normal PTT ... • Prolonged PTT ... Causes #Hematology #coagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... complexes with FVIIa ... TF-FVIIa also activates ... #Coagulation #Cascade ... thrombin #clot #PT #PTT