13 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... typically prolong aPTT ... Pre-analytical cause ... #Prolonged #Causes
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... Causes include : ... Pre-analytical cause ... , FVII, FIX, FX)
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Algorithm for Investigation ... PT - Prolonged aPTT ... PT - Prolonged aPTT ... DrEricStrong #Algorithm ... #Laboratory #Hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Thromboplastin Time (PTT ... warfarin) • Factor VII ... Thromboplastin Time (PTT ... thematttsai #PT #PTT ... Thromboplastin #laboratory
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
levels of factors VII ... venipuncture sites Laboratory ... Treat primary cause ... INR < 2.3 - APTT ... Coagulation #diagnosis #causes
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Causes of Prolonged ... INR), Prolonged PTT ... (INR), Normal PTT ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Chest Pain - Diagnosis and Workup Algorithm

History and Exam
Acute life-threatening causes:
 • Acute myocardial infarction
 •
Diagnosis and Workup Algorithm ... life-threatening causes ... LET, lipase, PT. aPTT ... Pain #Diagnosis #Algorithm
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
NORMAL PT/NORMAL PTT ... evaluation of factor VII ... Inherited: • Factor VII ... the PT and the PTT ... discern these causes
Post-abortion Hemorrhage Management Algorithm
Cervical laceration
 → Direct pressure, silver nitrate for small laceration
 → Repair with
Hemorrhage Management Algorithm ... atony or unsure of cause ... Repair Clinical or laboratory ... Hemorrhage #Management #Algorithm
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... performed PT, PTT ... decrease in most cases ... hematuria (without casts