31 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
unfractionated heparin ... FVIII antibody ... cause e.g. heparin ... thrombin inhibitors, heparin ... Prolonged #Causes #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... , FVII, FIX, FX ... Prolonged #Causes #diagnosis
Hearing Loss - Differential Diagnosis Framework

Hearing Loss Types:
• Conductive
• Sensorineural
• Mixed
Presbycusis is the most common type
Diagnosis Framework ... Hearing Loss ... cranial nerves V and VII ... auditory nerve (CN ... #Differential #Diagnosis
Labyrinthitis 
Vestibular neuritis + unilateral hearing loss = Labyrinthitis 
1) Vertigo (severe) 
2) Gait instability 
3)
neuritis + unilateral hearing ... 4) Unilateral hearing ... of vestibular CN ... Labyrinthitis #Diagnosis
Bell's Palsy - Diagnosis and Management Summary - GrepMed Handbook

Acute Idiopathic Unilateral Facial Nerve (CN7) Palsy
Presentation:
Bell's Palsy - Diagnosis ... neuropathies (ataxia, hearing ... , Sjogrens Diagnosis ... MRI+gad (stroke, CN7 ... #Bells #Palsy #Diagnosis
Types of Facial Paralysis - Peripheral vs Central Lesions

Facial weakness or paralysis may result either from
peripheral lesion of CN ... VII, the facial ... VII, exemplified ... #CNVII #CN7 #Peripheral ... Palsy #Neurology #Diagnosis
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
warfarin) • Factor VII ... elevated in: • Heparin ... laboratory #hematology #diagnosis
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
complexes with FVIIa ... TF-FVIIa also activates ... clot #PT #PTT #diagnosis ... Rivaroxaban #Edoxaban #heparin
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
levels of factors VII ... Thromboembolism (7%) • CNS ... deficiency) • HIT: Heparin-PF4 ... 100mg/dL) - Heparin ... #Coagulation #diagnosis
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
CNS Infection in ... - Differential Diagnosis ... cells per μL • Diagnosis ... visual changes, hearing ... #differential #diagnosis