13 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Congenital intrinsic coagulation ... FVIII antibody ... intravascular coagulation ... #differential #hematology ... #coagulation
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
, FVII, FIX, FX ... production Fll, FV, FVII ... , FVII, FIX, FX) ... #differential #hematology ... #coagulation
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Investigation of Abnormal Coagulation ... #Algorithm #Coagulation ... APTT #Laboratory #Hematology ... #Diagnosis #Workup
Coagulation Cascade - Anticoagulant Targets
Here's the brief overview of where the main anticoagulants work on the
Coagulation Cascade ... anticoagulants work ... Warfarin - II, VII ... /ambcarerx #Coagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... complexes with FVIIa ... TF-FVIIa also activates ... #Coagulation #Cascade ... diagnosis #models #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... levels of factors VII ... is simultaneous coagulation ... Thromboembolism (7%) • CNS ... treatment #management #hematology
Fever of Unknown Origin (FUO) - Further Workup

 • CNS symptoms? Get an LP and imaging
FUO) - Further Workup ... • CNS symptoms ... values supporting hematologic ... UnknownOrigin #workup
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... • Albumin • Coagulation ... #differential #Hepatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... evaluation of factor VII ... Inherited: • Factor VII ... intravascular coagulation ... Differential #Diagnosis #Hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
• ALP > 1.5 x ULN ... cholangitis #diagnosis #workup ... #hepatology