10 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Congenital intrinsic coagulation ... intravascular coagulation ... Jcortesizaguirr #Abnormal ... differential #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Diagnosis for a Prolonged ... aPTT are both prolonged ... , FVII, FIX, FX) ... amyloidosis #Abnormal ... differential #hematology #coagulation
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Algorithm for Investigation ... of Abnormal Coagulation ... PT - Prolonged ... DrEricStrong #Algorithm ... #Coagulation #Abnormal
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
PT (INR), Normal ... PTT, Normal PT ... PTT, Normal PT ... Differential #Diagnosis #Algorithm ... Causes #Hematology #coagulation
Normal Thromboelastogram - Specific parameters represent the 3 phases of the cell-based model of haemostasis: initiation,
Normal Thromboelastogram ... Diagnosis #Hematology #Coagulation ... #Thromboelastogram ... #TEG #Normal #Interpretation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... Thrombocytopenia • Prolonged ... levels of factors VII ... Thrombocytopenia - Normal ... - APTT < 1.5 x normal
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... the PT remains prolonged ... evaluation of factor VII ... Inherited: • Factor VII ... intravascular coagulation
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm
Blood Loss: >500mL post vaginal delivery OR >1000 mL
Differential Diagnosis Algorithm ... fatigue (e.g. prolonged ... succenturiate lobe • Abnormal ... intravascular coagulation ... (DIC) • Anti-coagulation
Thromboelastography (trademarked as TEG)
 • Graphical representation of the fibrin polymerization process
 • Point-of-care anti-coagulation monitoring
trademarked as TEG ... Point-of-care anti-coagulation ... routine transfusion algorithms ... Thromboelastography #Thromboelastogram ... #TEG #interpretation
Possible approach to empiric anticoagulation in COVID-19

Is D-dimer above '"1,000-2,000 ng/ml?
Contraindication to anticoagulation?
Check fibrinogen level and/or
thromboelastography (TEG ... R-time low or normal ... Fibrinogen level is normal ... Anticoagulation - R-time prolonged ... #criticalcare #algorithm