37 results
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Phytonadione), 4-factor ... PCC (Kcentra) - Heparin ... alfa (Andexxa), 4-factor ... PCC (Kcentra) #anticoagulation ... #pharmacology #hematology
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
Molecular Weight Heparin ... Warfarin - Selective factor ... Direct thrombin (factor ... - Dabigatran #anticoagulation ... medications #doac #comparison
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Deficiency of Factor ... Medications - Heparin ... • Acute DIC - Septic ... Summary #table #comparison ... #diagnosis #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Destruction • Abnormal ... Congenital • Factor ... Deficiency • Factor ... - Acquired • Anticoagulation ... #Causes #Hematology
Heparin - Unfractionated Heparin (UFH) vs Low-Molecular-Weight Heparin (LMWH)
UFH:
 • Advantages: 
    -
Heparin (UFH) vs ... clearance - Anticoagulation ... monitoring Of anticoagulation ... requires an anti-factor ... #comparison #Unfractionated
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... Decreased factor ... amyloidosis #Abnormal ... #differential #hematology
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Heparin, Fondaparinux ... Pathophysiology Anticoagulation ... warfarin) for chronic anticoagulation ... bind and inhibit factor ... that inhibits factor
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Dysplastic nodule, Hepatic ... Liver #Lesions #Hepatic ... Contrast #CT #MRI #POCUS ... differential #diagnosis #comparison ... table #appearance #hepatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
dysfunction (25%) • Hepatic ... Thrombocytopenia - Normal ... 100mg/dL) - Heparin ... - APTT < 1.5 x normal ... treatment #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
== NORMAL PT ... /NORMAL PTT: • ... VIII level NORMAL ... Acquired: • Heparin ... Differential #Diagnosis #Hematology