28 results
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
VIII level NORMAL ... Acquired: • Heparin ... PT/NORMAL PTT: ... deficiency • Liver ... Acquired: • Liver
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Deficiency of Factor ... Medications - Heparin ... ) • Advanced Liver ... • Acute DIC - Septic ... Summary #table #comparison
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver ... , Metastasis #Liver ... #Lesions #Hepatic ... Contrast #CT #MRI #POCUS ... differential #diagnosis #comparison
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
: <5 mg/dL • Hepatic ... imaging: Normal ... • Histology: Normal-mild ... imaging: Hepatic ... obstetrics #hepatitis #comparison
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... Decreased factor ... • Reduced liver ... amyloidosis #Abnormal
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... unfractionated heparin ... cause e.g. heparin ... Reduced liver synthesis
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
dysfunction (25%) • Hepatic ... Thrombocytopenia - Normal ... DIC • Severe Liver ... 100mg/dL) - Heparin ... - APTT < 1.5 x normal
Causes of Ascites - Differential Diagnosis Algorithm
Portal Hypertension - Prehepatic:
 • Portal vein thrombosis
 • Splenic
Differential Diagnosis Algorithm ... Hypertension - Hepatic ... disease • Acute liver ... Hypertension - Post-Hepatic ... Differential #Diagnosis #Algorithm
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Laboratory Findings in Hepatic ... rapid decline to normal ... and AST can be normal ... production of clotting factors ... #LiverFailure #Hepatic
Portal venous gas on hepatic ultrasound: A concerning finding in the critically ill patient that should
on hepatic ultrasound ... of air in the hepatic ... ischemia, perforated peptic ... ultrasound #hepatology #liver ... #pocus #clinical
►