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diagnosis hematology differential aptt bruising management treatment blanching bruise dic disorders disseminated ecchymosis hematomas hemophilia hemostasis inr intravascular petechiae ppt
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PT (INR), Normal ... PTT, Normal PT ... Differential #Diagnosis #Algorithm ... #coagulation #disorders
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... Jcortesizaguirr #Abnormal ... #PT #aPTT #Prolonged ... #Causes #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... PT/PTT • Low ... protein C and S Pathophysiology ... Fibrinogen: ↓ • PT ... #diagnosis #causes
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and aPTT If ... the PT and the ... amyloidosis #Abnormal ... #PT #aPTT #Prolonged ... differential #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... ) ABNORMAL PT ... prolonged after ... PT/ABNORMAL PTT
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Destruction • Abnormal ... Congenital • Factor ... Deficiency • Factor
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
disease) • aPTT is prolonged ... study (aPTT may be normal ... in mild cases) ... • PT/INR & von ... antigen (vWF:Ag) are normal
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
ecchymosis) is caused ... are typical of coagulation ... Excessive bruising & prolonged ... , PT should be normal ... Measurement of coagulation
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