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diagnosis management hematology oncology syndrome hemeonc chronic cll differential gastroenterology ibs irritable lymphocytic mds myelodysplastic neurology acute als amyotrophic aplastic
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... chronic onset of symptoms ... B-cell lineage ALL Symptoms ... -> AML: Blast crises ... - infiltrates (anemia
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic Leukemia ... • Most common leukemia ... lymphocytes, smudge cells ... of anemia or thrombocytopenia ... marrow failure with anemia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... only curative treatment
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... and petechiae Causes ... virus (EBV) • Leukemia ... Treatment: ... • Improve the symptoms
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Skin: - CLL cells ... or basket cells ... • Neutropenia, anemia ... microglobulin Treatment
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... Out Secondary Causes ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... factor (GCSF) treatments
Irritable Bowel Syndrome (IBS) - Management Global IBS Symptoms: - Limited trial low FODMAP diet
Irritable Bowel ... Management Global IBS Symptoms ... Rifaximin- up to 3 courses ... intestinal epithelial cells ... gastroenterology #treatment
Irritable Bowel Syndrome (IBS) - Diagnosis and Management Summary Diagnosis: • Use a positive diagnostic strategy with
Irritable Bowel ... for diagnosis Treatment ... Rifaximin- up to 3 courses ... intestinal epithelial cells ... IBS #Irritable #Bowel
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... Dehydration • Symptoms ... changes, stroke symptoms ... limb ischemia, bowel ... Lysis of tumor cells
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... to manifest its symptoms ... , alcohol use, symptoms ... Check for IF ab Treatment ... diagnosis e.g. leukemia
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