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Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
Hyperferritinemia Pearl: Diseases ... Still's disease ... histoplasmosis #Ferritin
Iron Deficiency Anemia vs Anemia of Chronic Disease - Laboratory Testing

SUMMARY:
 - RDW, FEP, serum iron,
Anemia of Chronic Disease ... - Ferritin-best ... Anemia #Chronic #Disease
Iron Deficiency Anemia - Differential Diagnosis Algorithm

Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR

 • Blood loss:
Algorithm Labs: Ferritin ... Structural: Celiac disease ... Diagnosis #Algorithm #ferritin
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... CRP, AST+ALT, ferritin ... AOSD: F>M, low ferritin ... AdultOnset #Stills #Disease
For an elderly patient with multiple comorbidities it can be challenging to determine if their anemia
anemia of chronic disease ... Anemia #Algorithm #Ferritin
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Onset Still's Disease ... • ↓Hgb • High ferritin ... the higher the ferritin ... the greater the disease ... onset #Stills #disease
POCUS Stewardship
Right Indication - Right Interpretation -Right Integration
Indication → Pre-test Probability → Spectrum of Disease →
→ Spectrum of Disease ... Ratio Step 1: Clinical ... with a focused clinical ... 3: Spectrum of Disease ... the spectrum of disease
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH) Clinical ... findings in HLH: ↑↑ ferritin ... cell lines) • ↑ ferritin
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
MCHC, Serum Iron, Ferritin ... Anemia of Chronic Disease
Gastrointestinal Evaluation of Iron Deficiency Anemia
In patients with anemia, diagnose iron deficiency if:
 • Ferritin <
deficiency if: • Ferritin ... Test for celiac disease