463 results
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH ... lab findings in HLH ... : ↑↑ ferritin, Anemia ... consistent with HLH ... cell lines) • ↑ ferritin
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
> 1000 Ferritin ... hepcidin prevents ferritin ... HLH or Adult Onset ... Sideroblastic anemia ... In adults, HLH is
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (sHLH ... lymphohistiocytosis (HLH ... hypersensitivity syndromes • HLH ... with leukopenia, anemia ... dehydrogenase • ↑ Ferritin
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
HLH 2. ... histoplasmosis #Ferritin
Iron Panel Interpretation

Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation,  ↓
Saturation, ↓ Ferritin ... Anemia of chronic ... Saturation, ↑-nl Ferritin ... Saturation, ↓-↑-nl Ferritin ... Saturation, ↑-nl Ferritin
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased Heme Synthesis or
Causes of Anemia ... Globin Synthesis Ferritin ... TlBC > 18% • Anemia ... Inflammation Ferritin ... #Microcytic #Anemia
For an elderly patient with multiple comorbidities it can be challenging to determine if their anemia
determine if their anemia ... deficiency as well as anemia ... Iron #Deficiency #Anemia ... #Algorithm #Ferritin
Iron Deficiency Anemia vs Anemia of Chronic Disease - Laboratory Testing

SUMMARY:
 - RDW, FEP, serum iron,
Iron Deficiency Anemia ... vs Anemia of Chronic ... - Ferritin-best ... Iron #Deficiency #Anemia
Iron Deficiency Anemia (IDA)
Tests:
 • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
Iron Deficiency Anemia ... synthesis • Ferritin ... Iron #Deficiency #Anemia ... #IDA #ferritin
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... / Diagnosis: HLH ... cell activity • Ferritin ... If no response HLH ... TheIDtrivia #HLH