78 results
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH ... lab findings in HLH ... : ↑↑ ferritin, Anemia ... consistent with HLH ... cell lines) • ↑ ferritin
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
> 1000 Ferritin ... hepcidin prevents ferritin ... HLH or Adult Onset ... Sideroblastic anemia ... In adults, HLH is
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
HLH 2. ... histoplasmosis #Ferritin
Iron Panel Interpretation

Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation,  ↓
Saturation, ↓ Ferritin ... Anemia of chronic ... Saturation, ↑-nl Ferritin ... Saturation, ↓-↑-nl Ferritin ... Saturation, ↑-nl Ferritin
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... / Diagnosis: HLH ... signs and symptoms ... cell activity • Ferritin ... If no response HLH
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Diagnosis Algorithm Signs ... of anemia and hemolysis ... Autoimmune Hemolytic Anemias ... #Hemolytic #Anemias
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased Heme Synthesis or
Causes of Anemia ... Globin Synthesis Ferritin ... TlBC > 18% • Anemia ... Inflammation Ferritin ... #Microcytic #Anemia
For an elderly patient with multiple comorbidities it can be challenging to determine if their anemia
determine if their anemia ... deficiency as well as anemia ... Iron #Deficiency #Anemia ... #Algorithm #Ferritin
Pathophysiology, Signs and Symptoms of Hemolytic Anemia

#Pathophysiology #Hemolytic #Anemia #hematology #diagnosis #signs #symptoms
Pathophysiology, Signs ... Symptoms of Hemolytic Anemia ... Pathophysiology #Hemolytic #Anemia ... hematology #diagnosis #signs
Iron Deficiency Anemia (IDA)
Tests:
 • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
Iron Deficiency Anemia ... synthesis • Ferritin ... Iron #Deficiency #Anemia ... #IDA #ferritin