113 results
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH ... lab findings in HLH ... : ↑↑ ferritin, Anemia ... consistent with HLH ... cell lines) • ↑ ferritin
Iron Panel Interpretation

Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation,  ↓
Interpretation Iron deficiency ... Saturation, ↓ Ferritin ... Anemia of chronic ... Iron deficiency ... Interpretation #deficiency
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
> 1000 Ferritin ... hepcidin prevents ferritin ... HLH or Adult Onset ... Sideroblastic anemia ... In adults, HLH is
Iron Deficiency Anemia - Differential Diagnosis Algorithm

Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR

 • Blood loss:
Iron Deficiency ... Anemia - Differential ... Algorithm Labs: Ferritin ... #Anemia #Differential ... Diagnosis #Algorithm #ferritin
Iron Deficiency Anemia vs Anemia of Chronic Disease - Laboratory Testing

SUMMARY:
 - RDW, FEP, serum iron,
Iron Deficiency ... Anemia vs Anemia ... TIBC-specific for iron deficiency ... - Ferritin-best ... #Anemia #Chronic
For an elderly patient with multiple comorbidities it can be challenging to determine if their anemia
determine if their anemia ... secondary to iron deficiency ... as well as anemia ... Diagnosis #Iron #Deficiency ... #Ferritin #Transferrin
Iron Deficiency Anemia (IDA)
Tests:
 • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
Iron Deficiency ... Anemia (IDA) Tests ... synthesis • Ferritin ... DharSaty #Iron #Deficiency ... #Anemia #IDA #ferritin
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased Heme Synthesis or
Causes of Anemia ... RBC>13 • Iron Deficiency ... Malabsorption, Dietary Deficiency ... ) Ferritin normal ... TlBC > 18% • Anemia
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
HLH 2. ... histoplasmosis #Ferritin
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... erythematosus • HLH ... B12 • Folate deficiency