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Diagnostic Schema for Hyperferritinemia Pearl: Diseases associated with extreme elevations: 1. HLH 2. Still's disease 3. Systemic
Diagnostic Schema ... HLH 2. ... histoplasmosis #Ferritin ... #Differential #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
: ↑↑ ferritin, Anemia ... IL-2 receptor Diagnostic ... Criteria): Molecular diagnosis ... cell lines) • ↑ ferritin ... Lymphohistiocytosis #diagnosis
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
- Differential Diagnosis ... Ferritin > 1000 ... HLH or Adult Onset ... In adults, HLH is ... #Differential #Diagnosis
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... and Differential Diagnosis ... and Screen for HLH ... HLH syndrome 5. ... #Pancytopenia #Workup
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Presentation / Diagnosis ... Diagnosis via genetic ... cell activity • Ferritin ... Infection should be diagnosed ... Lymphohistiocytosis #diagnosis
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... and Differential Diagnosis ... and Screen for HLH ... HLH syndrome 5 ... #Pancytopenia #Workup
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH ... Auto-amplification loop Diagnosis ... dysfunction, ↑ Ferritin ... hemophagocytosis = additional diagnostic ... Lymphohistiocytosis #diagnosis
Iron Panel Interpretation Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation, ↓
Saturation, ↓ Ferritin ... Saturation, ↑-nl Ferritin ... Saturation, ↓-↑-nl Ferritin ... Saturation, ↑-nl Ferritin ... Interpretation #deficiency #diagnosis
Primary Amenorrhea Differential Diagnosis Framework Workup: • β-HCG, TSH and PRL • Breast Tanner Staging • FSH,
Amenorrhea Differential Diagnosis ... Framework Workup ... Staging • FSH, LH ... #Differential #Diagnosis
Hemolytic Anemia - Hemolysis Diagnostic Workup Infographic by: Howard Ong #Hemolysis #Hemolytic #Anemia #Algorithm #MAHA #TTP #Diagnosis #Workup
Anemia - Hemolysis Diagnostic ... Workup Infographic ... Algorithm #MAHA #TTP #Diagnosis ... #Workup #Hematology
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