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diagnosis management differential dermatology arthritis dermatomyositis lupus sle symptoms systemic treatment vasculitis algorithm antimda5 antimda5dm antinxp2 antinxp2dm autoimmune biliary bronchiectasis
Rheumatoid Arthritis Summary MCP and PIP Involvement, Spares DIP, Carpal Tunnel, Sicca Syndrome, Epi/Scleritis, Heart Disease, Rheumatoid
Rheumatoid Arthritis Summary ... Rheumatoid Nodules, Pulmonary ... Disease and ILD ... RA #diagnosis #rheumatology ... #signs #symptoms
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
and progressive fibrosis ... : ILD (interstitial ... lung disease), ... Scleroderma #SSc #rheumatology ... symptoms #testing #workup
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
and Management Summary ... • Immunologic Workup ... Positive in 60-80% of cases ... Evolution: Chronic disease ... #rheumatology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... Inverse Gottron’s sign ... severity of the disease ... and ILD • Liver ... Dermatomyositis #rheumatology
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
Bronchiectasis - Summary ... : • Cystic fibrosis ... Connective tissue diseases ... Nasal polyps and signs ... , in advanced disease
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm Elevated Hemoglobin: • Males: Hb > 16.5 g/dL/HCT ≥ 49% •
Polycythemia - Acquired Causes ... Hypoxia-driven: Cardiac/pulmonary ... disease, Smoking ... , HCC, uterine fibroids ... Diagnosis #Algorithm #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) - Summary ... intralobular bile ducts causes ... failure PBC Signs ... cholangitis #diagnosis #workup ... #hepatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Summary ... thrombophlebitis, pulmonary ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... decrease in most cases ... hematuria (without casts ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... • Autoimmune diseases ... Drugs, Unknown cause ... management #treatment #summary ... #rheumatology
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