15 results
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
and progressive fibrosis ... Cardiac: myocardial fibrosis ... : ILD (interstitial ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Systemic Sclerosis ... fibrosis Anti-centromere ... progressive skin fibrosis ... Autoantibodies #diagnosis ... #rheumatology
Interstitial Lung Diseases (ILD)
Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): 
 • Hypersensitivity pneumonitis, Farmer's lung, Bird
Tissue Disease: • Systemic ... • Idiopathic pulmonary ... fibrosis (IPF), ... #diagnosis #differential ... #pulmonary #causes
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Initial screening test ... Treatment: • Mild ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm
Idiopathic Interstitial Pneumonia
 • (UIP) Usual Interstitial Pneumonia
- Differential Diagnosis ... Interstitial Pneumonia - fibrosis ... leaking out of pulmonary ... Rheumatoid Arthritis, Systemic ... Lung #Diseases #ILD
The idiopathic interstitial pneumonias (IIPs) comprise a heterogenous group of disorders. 
They represent fundamental responses of
combinations of fibrosis ... #Diagnosis #Radiology ... #Pulmonary #CTChest ... IdiopathicInterstitialPneumonia #ILD ... #Findings #RadiologyAssistant
Leptospirosis
Pathogen: Leptospira (interrogans, kirschneri, noguchii)
Risk Factors:
 • Occupational exposure - Farmers, ranchers, trappers, veterinarians
 • Recreational
rainwater catchment systems ... Presentation: • Mild ... failure • Severe pulmonary ... agglutination - test ... #treatment #management
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
• Homogeneous: Systemic ... , Interstitial Pulmonary ... Fibrosis, Multiple ... ANA #patterns #rheumatology ... #diagnosis #differential
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
-1 and IL-6, leading ... Liver function tests ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
fibrotic lesions ... • Skeletal system ... Tuberculosis Diagnosis ... Tuberculosis #TB #Diagnosis ... #Management #Treatment