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differential rheumatology algorithm antinxp2 antinxp2dm autoimmune classification clinical complications cutaneous dermatomyositis dermpath lesions lupus maculopapular management mucocutaneous myopathy myositis pathology
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
disease (10%) : SLE ... #dermpath #dermatology ... #semiology #signs ... #lesions #diagnosis ... #clinical #manifestations
Maculopapular - Diagnostic Algorithm Pathophysiology: - Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic ... Ill-appearing, vital sign ... #Dermatology #Rash ... Maculopapular #Scaling #Color ... #Differential #Ddxof
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Manifestations ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis ... #signs #symptoms
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... mucositis - Rash ... episcleritis as well as inner ... purpura: strong sign ... , and SLE) • Urinalysis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... diseases, such as SLE ... purpura: Strong sign ... , mucositis • Rash
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... chest (in a V-sign ... shoulders (in a shawl sign ... renal carcinoma • Colon ... #rheumatology #dermatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Symptoms: • Gottron rash ... papules and Gottron sign ... ) • Shawl sign ... flexors, quadriceps, finger ... Extramuscular manifestations
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