4 results
CREST Syndrome: Pathogenesis and Clinical Findings

CALCINOSIS (BB-sized, hard nodules in fingers)
RAYNAUD'S Phenomenon
ESOPHAGEAL DYSMOTILITY
SCLERODACTYLY (thickening and tightening
hard nodules in fingers ... tightening of skin ... TELANGIECTASIA (In face, hands ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Diffuse Systemic Sclerosis (Scleroderma)
 - Pulmonary Fibrosis -> Crackles, Abnormal CXR
 - Pulmonary Hypertension, Right Heart
nodules under skin ... ) - Finger/hand ... and bushy - Finger ... pathophysiology #signs ... #symptoms #diagnosis
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
or the anterior chest ... • Mechanic's hands ... #AntiMDA5DM ... #rheumatology #dermatology ... #diagnosis
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
) • Anti-Mi2 (skin ... ) • Shawl sign ... flexors, quadriceps, finger ... elevated < PM and DM ... • Mechanic's hands