62 results
CREST Syndrome: Pathogenesis and Clinical Findings

CALCINOSIS (BB-sized, hard nodules in fingers)
RAYNAUD'S Phenomenon
ESOPHAGEAL DYSMOTILITY
SCLERODACTYLY (thickening and tightening
Clinical Findings ... nodules in fingers ... tightening of skin ... CREST #Syndrome #Pathophysiology ... Diagnosis #Signs #Symptoms
Janeway Lesion: Flat, painless, erythematous lesions seen on the palm of this patient's hand. While
frequently associated
this patient's hand ... endocarditis, in this case ... Photo credit, Josh ... Fierer, M.D. ... #SkinRash #Janeway
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
clinical findings ... lesions in the inner ... retinal nerve fiber ... #Retinopathy #pathophysiology ... diagnosis #signs #symptoms
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
decades of life Causes ... and clinical associations ... duration of symptoms ... within one hour or longer ... angioedema Other symptoms
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
Systemic Symptoms ... Symptoms: • The ... Edema in 70% of cases ... Skin involvement ... Resolution > 15 days Differentials
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Management Summary ... survival is 93-95% Pathophysiology ... renal failure Clinical ... nodes: 13-15%, skin ... Sarcoidosis #Diagnosis #Management
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... postpartum): • Initial symptoms ... = nonspecific (nausea ... infiltration) Differential ... age • Monitor and
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Management Summary ... extrapulmonary cases ... Clinical Signs ... back pain - Symptoms ... decreased reflexes Pathophysiology
Bullous Pemphigoid - Diagnosis and Management Summary
Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
Management Summary ... Pathophysiology ... epidermis from dermis Clinical ... Signs/Symptoms/ ... crusts at sites
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Management Vitamin ... integrity of: • Skin ... poor nutrition Clinical ... Psychiatric symptoms ... , or any other cause