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diagnosis hematology anemia causes hemolytic agglutinin disease disorders extravascular hypertension hypertensive intravascular megacolon monoclonal obstetrics oncology paraproteinemias pregnancy toxic vasculitis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... uremic syndrome ... Autoimmune (AIHA)"Cold ... . primary cold agglutin ... Extravascular #Causes #differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Valves, AS - HTN ... Autoimmune: Warm AIHA, Cold ... Drug-associated, PCH, Evans Syndrome ... Diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... nose, ears, or fingers ... Diagnosis: • hemolytic ... younger pts) Differential ... #anemia #hematology
Hypertensive Disorders of Pregnancy Chronic Hypertension: • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg •
And Proteinuria (e.g ... patients • HELLP: Syndrome ... of hemolysis, elevated ... #obstetrics #cardiology ... #differential #
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
thrombosis+Pulm HTN ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Causes of Toxic Megacolon - Differential Diagnosis Framework • Inflammatory Bowel Disease: Ulcerative colitis, Crohn's colitis
Toxic Megacolon - Differential ... Cryptosporidiosis, Yersinia, Hemolytic-uremic ... syndrome (complicating ... Escherichia coli ... dilatation: 5-HT3
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Abdominal pain • HTN ... pulmonary infiltrates, hemoptysis ... infiltrates/cavities, hemoptysis ... #Diagnosis #Rheumatology
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