14 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... uremic syndrome ... cold agglutin disease ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Valves, AS - HTN ... Drug-associated, PCH, Evans Syndrome ... #Differential # ... Diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... for workup, including ... blood loss, Acute hemolysis ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... nose, ears, or fingers ... younger pts) Differential ... #hemolytic #anemia ... #hematology #diagnosis
Primary and Secondary Causes of Hypertension - Differential Diagnosis Algorithm
Primary (Essential) (95%) - Onset between age
Hypertension - Differential ... taken at home, work ... excess (Cushing syndrome ... Primary #Secondary #HTN ... #Cardiology #Differential
Hypertensive Disorders of Pregnancy
Chronic Hypertension:
 • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg
 •
And Proteinuria (e.g ... patients • HELLP: Syndrome ... of hemolysis, elevated ... #obstetrics #cardiology ... #differential #
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Symptoms of Joint Disease ... -60 minutes or longer ... Joint #Pain #MSK #rheumatology ... #approach #workup ... #differential #
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Hypertension - Workup ... and Differential ... Renal parenchymal disease ... most pts have HTN ... #Hypertension #Workup
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... thrombosis+Pulm HTN ... • Coombs (-) hemolytic ... Sneddon-Wilkinson disease ... #Monoclonal #Differential
Noncardiogenic Pulmonary Edema - Differential Diagnosis Framework

NCPE Pathophysiology:
Noncardiogenic pulmonary edema occurs because of excessive pulmonary capillary
Pulmonary Edema - Differential ... acute cardiac disease ... respiratory distress syndrome ... • Pulmonary HTN ... #diagnosis #cardiology