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diagnosis hematology causes management oncology thrombocytosis agglutinin algorithm classification cold cvid dermatology disease gap globulin hemolytic hodgkins hypogammaglobulinemia immunodeficiency immunology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... malignancies • Anemia ... iron deficiency, hemolysis ... Myelodysplastic syndrome ... #secondary
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... nose, ears, or fingers ... symptoms - most common ... younger pts) Differential ... #anemia #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... leakage of RBC's secondary ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... #rheumatology #
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Most common cytopenia ... DDX: Rule Out Secondary ... Workup: • Complete ... blood count with differential
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... and autoimmune hemolytic ... anemia) • Systemic ... : • Nephrotic syndrome ... (Epstein-Barr syndrome
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Neutropenia - Differential ... Chediak-Higashi syndrome ... drug reactions - Secondary ... Megaloblastic anemia-rare ... - Secondary autoimmune
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... anemia • Pain ... (NSHL) - (most common ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Nodosa: • PAN most commonly ... pulmonary infiltrates, hemoptysis ... infiltrates/cavities, hemoptysis ... #Diagnosis #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... Thalassemia, Sickle cell anemia ... Comment on type ... Gap #ProteinGap #differential
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