26 results
Ethylene Glycol Toxicity

#Pathophysiology #Toxicology #EthyleneGlycol #Metabolism #Fomepizole
Ethylene Glycol Toxicity ... #Pathophysiology ... #Toxicology #EthyleneGlycol ... #Metabolism #Fomepizole
Acetaminophen metabolism and factors affecting toxicity. 
GSH = glutathione 

#Acetaminophen #APAP #metabolism #toxicity #Toxicology #Pathophysiology #Overdose
Acetaminophen metabolism ... factors affecting toxicity ... Acetaminophen #APAP #metabolism ... #toxicity #Toxicology ... #Pathophysiology
Cyanide Toxicity 
Treatment:
1) Hydroxocobalamin + Cyanide = Cyanocobalamin (nontoxic) 
   or 
2) Amyl nitrite
Cyanide Toxicity ... #Cyanide #Toxicity ... #Toxicology #Pathophysiology
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... use in cellular metabolism ... via anaerobic metabolism ... LacticAcidosis #Toxicity ... #Toxicology #Diagnosis
N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in
route of APAP metabolism ... conjugate the toxic metabolite ... routes of liver metabolism ... #Pathophys #Toxicology ... Acetaminophen #Toxicity
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Colchicine Toxicity ... Renal failure • Metabolic ... #Colchicine #Toxicity ... #Toxicology #Symptoms
Toxic Alcohol Ingestion
Alcoholic ketoacidosis - Methanol - Ethylene glycol - Isopropyl Alcohol
 • Metabolic Acidosis
 •
Isopropyl Alcohol • Metabolic ... Ingestion #diagnosis #toxicology ... #comparison #table
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... show anion-gap metabolic ... Labs: Anion-Gap Metabolic ... Salicylate #Aspirin #Toxicity ... #Toxicology #diagnosis
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
described phases of toxicity ... absent in severe toxicity ... deterioration Shock and metabolic ... - Anion gap metabolic ... #Toxicology #Diagnosis
Toxidromes Compared: Anticholinergic, Cholinergic, Opioid, Sympathomimetic, Sedative-Hypnotic

During your physical exam, look for evidence of some of
acute cholinergic toxicity ... Opioid toxicity ... #Diagnosis #Toxicology ... #Toxidromes #Comparison