6 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
nephrocalcinosis • CPPD ... severe mobility/functional ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
) Pathophysiology ... calcium to form CPP ... pain, loss of function ... Deposition #Disease #Rheumatology ... #diagnosis #management
Hypophosphatemia and Hypoxia - Pathophysiology

↓ Phosphate leads to ↓ red cell 2,3-DPG and a  reduction
and Hypoxia - Pathophysiology ... impacts respiratory function ... expiratory pressures in pts ... Phosphate is a cause ... respiratory #hypoxia #pathophysiology
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis - Management ... Algorithm Assess ... Maddrey Discriminant Function ... exclude other causes ... #Algorithm #hepatology
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
subcutaneous edema Pts ... Muscle atrophy may cause ... and diminished functional ... Dermatomyositis #diagnosis #management ... dermatology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome caused ... Pathophysiology ... Impaired cytotoxic function ... #Hematology #HemeOnc