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diagnosis extravascular hemolytic agglutinin algorithm bloodcell cold common cvid disease hypogammaglobulinemia immunology management microscopy morphology nomenclature rbc red secondary thrombocytosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... lymphoproliferative disorders ... #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Hemolysis - Differential ... • Alloimmune ... anemia • ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... iron deficiency, hemolysis ... inflammatory disorders ... (e.g. autoimmune ... #hematology #secondary
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Unstable hemoglobin disorders ... hemolytic anemia ... hemolytic anemia ... #diagnosis #hematology ... #microscopy #atlas
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... Viral infection, autoimmune ... younger pts) Differential ... the RBCs causing intravascular ... #anemia #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disorder with hypogammaglobulinemia ... specifically immune thrombocytopenia ... hemolytic anemia ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
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