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diagnosis differential @dharsaty aafp algorithm ascorbicacid decrease dm2 eas elevation false folate folicacid fructosamine glycatedproteins hematology hemoglobina1c hgba1c homocysteine increase
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
and Reduction in HbA1c ... Iron, B-12, or folate ... blood loss • Hemolytic ... anemia • Splenomegaly ... Elevation #Reduction #HbA1c
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Index < 2: • Anemia ... , Vitamin B12, Folate ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... differential #diagnosis #calculation
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
of macrocytic anemia ... Hemorrhage or hemolysis ... elevated, but anemia ... but undiagnosed, folate ... #VitaminB12 #Folate
Hemoglobin A1c (glycated hemoglobin) reflects the average blood glucose concentration over the course of the RBC
span, such as hemolytic ... anemia or blood ... lifespan of RBCs in circulation ... in sickle cell anemia ... test, such as anemia
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
breath, wasting, anemia ... Loss of teeth Anemia ... lead to iron and folate ... contribute to nonimmune hemolysis ... #AscorbicAcid #Pathophysiology
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