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diagnosis differential hematology algorithm deficiency causes folate b12 folicacid homocysteine macrocytosis management mcv mma pancytopenia signs symptoms vitamin workup aafp
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Hypoproliferative Macrocytic ... Anemia • 812 ... , Folate Deficiency ... MatthewHoMD #Macrocytic ... #Anemia #differential
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
evaluation of macrocytic ... but undiagnosed, folate ... #Macrocytosis #Macrocytic ... #Anemia #VitaminB12 ... #Folate #FolicAcid
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... Framework by MCV Microcytic ... Sideroblastic anemia ... Infections Macrocytic ... Megaloblastic: Folate
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Framework for Anemia ... MCV - <80fL - "Microcytic ... thalassemia • Anemia ... MCV - >96fL - "Macrocytic ... B12 deficiency, Folate
Micronutrient Deficiencies After Gastric Bypass Fat-Soluble Vitamins: • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
cardiomyopathy) • Folate ... - Macrocytic anemia ... Vitamin B12 - Macrocytic ... anemia, cognitive ... Bypass #vitamin #nutrition
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Drugs Oval Macrocytes ... Neutrophils - Low RBC Folate ... Rule out B12 and Folate ... Liver Disease #Macrocytic
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology Microcytic ... Iron deficiency anemia ... Chronic disease anemia ... (sometimes) Macrocytic ... Vitamin B12 or Folate
Diagnosing Vitamin B12 and/or Folate Deficiency It turns out that simply measuring serum levels of B12 or
Vitamin B12 and/or Folate ... levels of B12 or folate ... Since folate is ... #VitaminB12 #Folate ... Deficiency #Diagnosis #Nutrition
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • B12/folate
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
E - Haemolytic anaemia ... paraesthesiae • Folate ... - Anaemia, neural ... Vitamin B12 - Anaemia ... signs #symptoms #nutrition
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