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diagnosis oncology liver transaminitis workup agglutinin algorithm alkaline alp causes chemistry clinical cold disease disorders gammopathy gap globulin hemolytic hyophosphatasia
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Anemia - Underproduction ... Iron deficiency anemia ... disorder - TSH, LFTs ... Underproduction #Algorithm #hematology ... #diagnosis #differential
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Monoclonal Gammopathy ... Significance (MGUS) - Differential ... Diagnosis Neurologic-Centered ... Significance #MGUS #Differential ... #Diagnosis #hematology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
normal - Hemolysis, NASH ... Liver #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... younger pts) Differential ... disease #hemolytic #anemia ... #hematology #diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Entities That Can Feature ... et diutinum Neurologic ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... (CVID, WAS), (neurologic ... changes), high MCV anemia ... gastric bypass), LFT ... Causes #Workup #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... disease: > 2 • NASH ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
• recurrent fractures ... • Pernicious anemia ... respiratory failure • Neurologic ... pain - Frequent fractures ... Hyophosphatasia #hepatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
blood cell count (anemia ... • Aplastic Anemia ... characteristic feature ... blood count with differential ... Syndromes #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Causes of Monoclonal ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential ... #diagnosis #hematology
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