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Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
the patient has hematuria ... have glomerular hematuria ... (RBC casts or dysmorphic ... RBCs in urine)? ... Comparison #Algorithm #Nephrology
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... hematuria. ... RBC casts in urine ... but in severe cases ... #Proteinuria #Nephrology
Differentiation Between Nephrotic Syndrome and Nephritic Syndrome 
== Nephrotic Syndrome ==
Onset - Insidious 
Edema - ++++
Blood
Proteinuria - ++++ Hematuria ... Red blood cell casts ... Proteinuria - ++ Hematuria ... edgarvlermamd - Nephrology ... Comparison #Table #Nephrology
Glomerular Diseases - Spectrum
 - Insidious vs Acute
 - Nephritic (hypertension, hematuria, renal failure) vs Nephrotic
Insidious vs Acute - Nephritic ... (hypertension, hematuria ... renal failure) vs Nephrotic ... differential #diagnosis #nephrology
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Hematuria Workup ... Algorithm • Confirm hematuria ... → Refer to Nephrology ... cystoscopy • Refer to Nephrology ... if cause not identified
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
: Red/Dark urine ... 1ml blood/liter urine ... more RBC/HPF spun urine ... examination of urine ... #urology #nephrology
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... blood cells on urine ... • Hereditary nephritis ... and >3.5g/day (nephrotic ... Diagnosis #Algorithm #Causes
Nephrotic Syndrome - Primary vs Secodary - Differential Diagnosis Algorithm

#Nephrotic #Syndrome #Differential #Diagnosis #Algorithm #Primary #Secondary
Nephrotic Syndrome ... Diagnosis Algorithm #Nephrotic ... Primary #Secondary #Nephrology ... #Causes
Causes of Hematuria - Differential Diagnosis
Renal:
 - Glomerular - IgA Nephropathy, Thin basement membrane, Alport syndrome,
Causes of Hematuria ... - Interstitial nephritis ... #Hematuria #Differential ... #Diagnosis #Causes ... #urology
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
and concentrated urine ... tubulointerstitial nephritis ... tuberculosis Fatty - Nephrotic ... edgarvlermamd - Nephrology ... Microscopy #Diagnosis #Nephrology