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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE #hematology ... #rheumatology # ... differential #diagnosis
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
- Differential Diagnosis ... deficiency) • Infection ... Sepsis • Non-infectious ... (malignancy, rheumatologic ... causes #Platelets #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... → Refer to hematology ... : Chronic infections ... #Differential #Diagnosis ... #Algorithm #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
- Differential Diagnosis ... and non-hematologic ... malignancies • Infection ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Causes of Leukocytosis and Leukopenia - Differential Diagnosis
 • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
- Differential Diagnosis ... Connective Tissue, Infections ... Lymphocytosis: Infection ... #Differential #Diagnosis ... #causes #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
- Differential Diagnosis ... Myelofibrosis Infectious ... Non malignant hematologic ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Isolated Neutropenia - Differential Diagnosis Algorithm
Chronic (>3 months):
 • Extrinsic: Vitamins
 • Intrinsic: Congenital, Inflammatory
Transient:
 •
- Differential Diagnosis ... Inflammation: Infectious ... , Non-infectious ... #Differential #Diagnosis ... #Algorithm #hematology
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm
 • Reactive (Inflammatory / Infectious)
 •
- Differential Diagnosis ... Inflammatory / Infectious ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Causes of Hemolytic Anemia - Differential Diagnosis
Inherited
 • Membrane
 • Internal
    - Hemoglobin
- Differential Diagnosis ... Internal - Infectious ... #Differential #Diagnosis ... #Causes #hematology
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
suspect underlying hematologic ... disorders • Diagnosis ... Syndrome #HES #Hematology ... #eosinophils #diagnosis