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diagnosis differential hematology folicacid aafp approach classification dm2 false hba1c hgba1c homocysteine increase laboratory macrocytic macrocytosis mma neutropenia pancytopenia reduction
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... Iron, B-12, or folate ... deficiency • ... • Hemolytic anemia ... #Decrease #Diagnosis
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Decreased Megakaryopoiesis ... • Aplastic Anemia ... • Folate Deficiency ... • Folate Antagonist
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Deficiency • Decreased ... have hemolytic anemia ... that can cause ... anticonvulsants lead to increase ... diagnosis #hematology #nutrition
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... Reticulocytes • Iron Deficiency ... • B12/Folate ... Deficiency • Aplastic ... #Causes #Hematology
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
Algorithm for the ... the most likely cause ... recovery also causes ... an elevation in ... #VitaminB12 #Folate
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