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diagnosis differential causes classification mcv workup approach dm2 false hba1c hgba1c increase laboratory reduction testing thromboticthrombocytopenicpurpura ttp
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False Elevation ... Iron, B-12, or folate ... blood loss • Hemolytic ... anemia • Splenomegaly ... End-stage renal disease
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... , CKD • Hemolytic ... Megaloblastic: Folate ... Non-megaloblastic: Liver disease ... Differential #Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... without platelet decrease ... #Anemia #Differential ... #workup #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Differential Diagnosis Algorithm ... • Bleeding • Hemolysis ... Deficiency • Folate ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... Deficiency • B12/Folate ... Disease • Marrow ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... result in severe anemia ... anemia Indirect ... Mild-to-moderate elevation ... Diagnosis #Workup #Hematology
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