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diagnosis hepatology causes lfts transaminitis algorithm hepatitis infectiousdiseases lactate obstetrics pregnancy abnormal acidosis aflp anemia cardiology chemistry comparison dehydrogenase disease
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Mild jaundice, Elevated ... to 10-20-fold elevation ... , no necrosis HELLP ... to 10-20-fold elevation ... hepatitis #comparison #differential
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Elevated Transaminases ... Transaminitis - Differential ... • Congenital: HELLP ... Trauma: Shock liver ... Transaminitis #Elevated
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... • Pregnancy: HELLP ... specificity to elevated ... Bilirubin - +/- elevation ... Enzyme Elevation
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Pregnancy - AFLP, HELLP ... #LiverEnzymes #Differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
specificity to elevated ... Bilirubin - +/- elevation ... or amyloid: • Elevation ... Enzyme Elevation ... chemistry #diagnosis #differential
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... Extrinsic Causes: • Liver ... TTP, HUS, DIC, HELLP ... Hemolytic #Anemia #Differential ... Diagnosis #causes #classification
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Pregnancy - AFLP, HELLP ... kwburak #LFTs #Elevated
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate Elevation ... Lactic Acidosis - Differential ... Causes of elevated ... #Differential # ... #typea #typeb #classification
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Hyperferritinemia - Differential ... is made in the liver ... saturation to differentiate ... inflammatory causes of elevated ... extreme ferritin elevation
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