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diagnosis hematology hepatology anemia extravascular hemolysis hepatitis intravascular liver workup aflp alkaline alp classification comparison disease icp injury lfts liverenzymes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... coagulation (DIC) - HELLP ... Intrinsic RBC Defects: Enzyme ... Extravascular #Causes ... #differential #
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential ... Diagnosis Algorithm ... elliptocytosis - RBC Enzyme ... #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... : • Enzyme deficiencies ... TTP, HUS, DIC, HELLP ... #Anemia #Differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... deficiency, Other enzyme ... thrombocytopenia - DIC, TTP, HELLP ... #Anemia #Differential
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential ... Diagnosis Algorithm ... ALP: - Enzymes ... Intestine - Other causes ... #Differential #
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
to 10-20-fold elevation ... , no necrosis HELLP ... Syndrome (Hemolysis ... Elevated Liver enzymes ... hepatitis #comparison #differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Diagnosis Algorithm ... Pregnancy - AFLP, HELLP ... #Causes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... Diagnosis Algorithm ... Vascular Causes ... • Pregnancy: HELLP ... Source of Liver Enzyme
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
value for this enzyme ... decrease in most cases ... Mild-to-moderate elevation ... WBC count and differential ... hematuria (without casts
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