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diagnosis causes lactate rheumatology testing workup acidosis algorithm cardiology classification dehydrogenase dermatology dm2 elevated erythematosus false hba1c hemolytic hepatic hepatology
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
== Decreased RBC ... • Asplenia Laboratory ... • Hemolytic anemia ... HbA1c #HgbA1c #Laboratory ... Diagnosis #DM2 #Differential
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... ALT and AST - Elevations ... deficiency - Anemia ... leads to chronic anemia ... #Laboratory #Diagnosis
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... result in severe anemia ... Mild-to-moderate elevation ... WBC count and differential ... Diagnosis #Workup #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... without platelet decrease ... bartonella (oroya fever ... Algorithm #workup #hematology
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Hyperferritinemia - Differential ... Decreased hepcidin ... Hematologic Malignancy ... Sideroblastic anemia ... extreme ferritin elevation
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... - Hemolytic anemia ... Fragility: • Decreased ... mountain spotted fever ... #Diagnosis #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... myocarditis, rheumatic fever ... Idiosyncratic LDH Elevation ... Dehydrogenase #Elevated #differential ... #diagnosis #Laboratory
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... - assess other laboratory ... muscle use • Decreased ... 30mmHg) - Severe anemia ... #Differential #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... ) and laboratory ... permanent alopecia Differential ... lymphopenia, low PLT • Anemia ... to: Arthritis, Fever
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Hematologic malignancy ... Presentation: Fever ... gastrointestinal symptoms (elevations ... Bone Marrow - Anemia ... NTM #Infections #differential
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