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diagnosis causes management lactate syndrome acidosis criticalcare hematology lactic nephrology pulmonary rheumatology testing treatment workup acute adultonset algorithm anemia antimda5
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
• Asplenia Laboratory ... Reduction == Increase ... HbA1c #HgbA1c #Laboratory ... #Increase #Decrease ... Diagnosis #DM2 #Differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... Mild-to-moderate decrease ... Platelet count - Decreased ... Mild-to-moderate elevation ... WBC count and differential
Tuberculous Pleural Effusions - Tests and Biomarkers Age + fever + red blood cells + ADA -
Biomarkers Age + fever ... IFN-y + NAAT - Increase ... #Tuberculosis #Laboratory
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Hyperferritinemia - Differential ... Increased hepcidin ... Decreased hepcidin ... levels will cause increased ... extreme ferritin elevation
Laboratory Evaluation of Patients for Thyroid Disease Hyperthyroidism: • Graves disease - TSH low; free T4
Laboratory Evaluation ... high; normal or increased ... ; decreased radioactive ... sedimentation rate normal; decreased ... #hyperthyroid #differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... without platelet decrease ... bartonella (oroya fever ... Hemolytic #Anemia #Differential
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... inflammation: Increased ... Hyperferritinemia, decreased ... fraction < 20% Differential
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Emergencies - Differential ... death Neutropenic Fever ... , hypotension, increased ... • Vomiting, decreased ... emergencies #oncology #differential
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
Lactic Acidosis - Differential ... Delivery (DO2) • Decreased ... Compartment Syndrome • Increased ... Pain / Exercise, Fever ... Syndrome, where decreased
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... - assess other laboratory ... Circulatory System • Increased ... muscle use • Decreased ... #Differential #
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