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diagnosis causes rheumatology workup acidosis adultonset algorithm anemia antimda5 antimda5dm aspergillus betadglucan biomarkers bronchiectasis cancer classification comparison dermatology dermatomyositis disease
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
• Asplenia Laboratory ... Reduction == Increase ... HbA1c #HgbA1c #Laboratory ... #Increase #Decrease ... Diagnosis #DM2 #Differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... Mild-to-moderate decrease ... Mild-to-moderate elevation ... WBC count and differential ... Diagnosis #Workup #Hematology
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Increased hepcidin ... Decreased hepcidin ... levels will cause increased ... Hematologic Malignancy ... extreme ferritin elevation
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... without platelet decrease ... bartonella (oroya fever ... Hemolytic #Anemia #Differential ... Algorithm #workup #hematology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... inflammation: Increased ... Hyperferritinemia, decreased ... fraction < 20% Differential ... management #treatment #rheumatology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Emergencies - Differential ... Diagnosis Framework HEMATOLOGIC ... death Neutropenic Fever ... , hypotension, increased ... • Vomiting, decreased
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
Dermatomyositis • Fever ... no significant elevation ... Ferritinemia increases ... ILD worsens Decreased ... #dermatology #diagnosis
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... - assess other laboratory ... Circulatory System • Increased ... muscle use • Decreased ... #Differential #
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) in hematologic ... and should not increase ... BAL GM does not differentiate ... - Sensitivity decreased ... post-2010 almost never
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
run-down or tired • Fevers ... Superimposed infection - increase ... Bronchoscopy Laboratory ... Bronchiectasis #pulmonary #differential
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